Description

This program introduces students to the basic concepts of modern pharmacology. This unit provides the study of drugs and xenobiotics: chemicals that affect living systems. Topics covered will include the fundamentals of their action and the molecular basis of disposition. Lectures will consider the pharmacologic mechanisms by which chemicals may interfere with physiologic functions to cause abnormal side effects. Therefore the course of “Toxicology” included into program. In general, the program consists of a detailed account of the pharmacology of drugs and xenobiotics that affect selected organ systems. These include the pharmacology of substances affecting the endocrine system, the respiratory system, the digestive system, the immune system and the central nervous system. Emphasis is given to the clinical application of pharmacology in therapeutics through specifically-designed workshops that focus on case-studies. GLP and GCP approaches will be considered. Acquisition of new knowledge of biochemical processes in normal physiology and pathologies broadcast of this knowledge in new technologies for the further development of pharmacology will be investigated. For today the education in pharmacology is highly demanded over the world included Russia. The announcing program is unique for Russia and will train specialists in the field of chemical pharmacology and toxicology, drug design, drug and xenobiotics metabolism and disposition. The leading scientists of NSU who are currently working in the field of chemistry, biology and pharmacology will participate in the announced program.

Program goal

This program introduces students to the basic concepts of modern pharmacology. The announcing program is unique for Russia and will train specialists in the field of chemical pharmacology and toxicology, drug design, drug and xenobiotics metabolism and disposition.

Duration of study

Two academic years

Language of instruction

English

List of proposed lecture courses

  • Drug metabolism and disposition
  • Molecular Pharmacology
  • Signal molecules as targets for therapy
  • Analytical chemistry of drugs and biological active substances
  • Toxicology
  • Biotechnology in pharmacology
  • Physiological chemistry of drugs
  • Biologically active substances of living organisms
  • Pharmacologically active substances of new generation

Dissertation

  • Trace elements (mercury, arsenic, lead etc.) metabolism (transformation) in living systems
  • MicroRNAs as are targets for anti-cancer therapy

Training base

International partners

Department of Environment Toxicology, UC Davis, USA


Key personnel

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Lyudmila Gulyaeva

Dr. Lyudmila Gulyaeva is currently head of the Laboratory of Molecular Carcinogenesis of Federal Research Center “Fundamental and Translational Medicine”. She graduated from Novosibirsk State University in 1977 as biologist. Since 1997 – Professor of the Department of Natural Sciences of Novosibirsk State University; Since 2000 – Professor of the Medical Department of Novosibirsk State University. She prepared and lectured on "Ecological Biochemistry", “Molecular Mechanisms in Toxicology”. Since 1990 – supervisor of 55 students of the Novosibirsk State University (Department of Natural Sciences, Chair of Molecular Biology). Supervisor of eleven Ph.D. theses of graduate students, presented in period 2000 – 2018. Research interests: Drug Metabolism; Cytochrome P450; Regulation of Gene Expression; Carcinogenesis; Signal Transduction; Nuclear Receptors; Human Estrogen-Related Cancer; Genetic Polymorphism, Predisposition to Cancer; microRNAs. The results of her scientific activity were published in more than 190 papers in peer reviewed scientific journals.

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Valentin Vavilin

Dr. Valentin Vavilin is director of the Institute of Molecular Biology and Biophysics of Federal Research Center “Fundamental and Translational Medicine”, head of the Laboratory of Drug metabolism and Pharmacokinetics. He graduated from the medical faculty of Novosibirsk State Medical Institute in 1976. Since 2003 – associate Professor of the Department of Natural Sciences of Novosibirsk State University; since 2007 – Professor of the Department of Natural Sciences of Novosibirsk State University. He prepared and lectured on "Toxicology", “Physiological chemistry of drugs”. Supervisor of 10 Ph.D. theses and 1 D. Sci. theses. Research interests: Pharmacogenetics, Drug Metabolism & Disposition; Side effects of Drugs; Xenobiotic-dependent Regulation of Gene Expression; Mechanisms underlying the relationship between xenobiotic-metabolizing systems and the development of multifactorial diseases.

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Olga Shuvaeva

Dr. of Sci. Olga Shuvaeva is a head of Environmental Chemistry Chair of Natural Sciences Department at Novosibirsk State University, Leading Researcher at the Institute of Inorganic Chemistry SB RAS. She acts as principal investigator in Cooperation Agreement between NSU (Russia) and Tianjin University (China), a member and chairperson of the committees in International and National Scientific Conferences and Workshops, invited Expert of Federal Service for Supervision of Natural Resources, Siberian District, Member of the Scientific Council on Analytical Chemistry, SB RAS, lectured on “Environmental protection”, “Environmental Analytical Chemistry”, “Analytical Chemistry of Biologically Active Substances” and “Hot Points in Chemistry”. Supervisor of 35 students of NSU (Narural Sciences Department) and PhD of 5 graduates. The author of more than 70 publications in reputed journals. The field of research interests: trace elements determination and speciation to study their transformation and transport in environmental and living systems using separation techniques (HPLC and capillary electrophoresis, CE), atomic-absorption, atomic-emission and mass-spectrometric methods (ETA and FAAS, DCP-arc, ICP-AES and ICP-MS) as well as hyphenated technique HPLC-ICP-AES, HPLC-ICP-MS, CE-ICP-MS.

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Andrey Chibiryaev

Dr. Andrey M. Chibiryaev currently is a lead researcher of the Laboratory of processes in high density media (Boreskov Institute of Catalysis, Siberian Branch of the RAS). His present research interest is an organic synthesis and chemical transformations of naturally occurring substances (monoterpenoids and so on) in supercritical fluids, especially in lower alcohols. He graduated from Novosibirsk State University in 1989 as an organic chemist. The doctoral research titled ”Study of nitrosation reactions of cyclic α,β-unsaturated oximes” was completed in 1997 under the supervision of Prof. Alexey V. Tkachev (Vorozhtsov Institute of Organic Chemistry, Siberian Branch of the RAS). In 2002–2007 he was a head of the research group (Vorozhtsov Institute of Organic Chemistry). Doing the research, he was a supervisor of four Ph.D. theses of postgraduate students. Since 1997, A.M. Chibiryaev is a staff member of the Department of Natural Sciences of Novosibirsk State University. In 2005 he was appointed as an Associate Professor at the Novosibirsk State University and Vorozhtsov Institute of Organic Chemistry (Siberian Branch of the RAS). Presently, he is a lecturer of special course titled ”Biologically Active Substances of Living Organisms” of the Department of Natural Sciences (NSU).

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Marina Polovinka

Dr. Marina Polovinka, Ph.D., Associate Professor, in 1979 she graduated from Novosibirsk State University as a chemist. Since 2003, lecturer of the Chair of Organic Chemistry of Department of Natural Sciences, Novosibirsk State University, associate professor, since 2011 lecturer of the course "Methodology of organic synthesis". Research Interests: Study of the mechanisms of rearrangement of terpenoids in superacids by direct observation with NMR of the resulting cations in superacids. Study of the chemical composition of lower and higher plants (lichens, medicinal plants). Conducting chemical modification of plant metabolites in order to increase pharmacological activity. Working out together with the the Russian Academy of Agricultural Sciences new ecological preparations for combating the main plant diseases, developing new insecticides together with the biologists of the SB RAS on the basis of lichen metabolites and their derivatives. Development of new approaches in the treatment of joint diseases jointly with the staff of the Institute of Chemical Biology and Fundamental Medicine of the SB RAS. From 1979 to the present, Marina Polovinka has published more than 130 works in various author's collectives, including publications in Russian and foreign scientific journals, chapters in books, patents, monographs. She was the head of the graduate 9 and 3 Ph.D.

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Michail Chanyshev

Dr. Michail Chanyshev is senior research fellow of the Laboratory of Molecular Carcinogenesis of Federal Research Center “Fundamental and Translational Medicine”. 2009 - BSc. in Chemistry, Novosibirsk State University, 2011 - MSc. in Chemistry, Novosibirsk State University, 2014 - Ph.D. in Biochemistry, Institute of Molecular Biology and Biophysics. He prepared and lectured «Biotechnology in pharmacology» since 2016. Research interests: Molecular Biology. Chemically induced Carcinogenesis. MicroRNAs. Xenobiotics. Regulation of gene expression by microRNAs. In 2014-2018 he participated in Russian Foundation of Basic Research and Russian Science Foundation projects related to the study of epigenetic mechanism of xenobiotic action. He is author of 10 publications in Russian and International scientific journals.

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Andrey Yarushkin

Dr. Andrey Yarushkin is senior researcher of the Laboratory of Molecular Carcinogenesis of Federal Research Center “Fundamental and Translational Medicine”. 2009 - BSc. in Chemistry, Novosibirsk State University, 2011 - MSc. in Chemistry, Novosibirsk State University, 2014 - Ph.D. in Biochemistry, Institute of Molecular Biology and Biophysics. His PhD thesis:”Species-specific effect of 2,4,6-triphenyldioxane-1,3 derivatives on constitutive androstane receptor activation and gluconeogenic genes expression”. His research interests are: Cytochrome P450, drug metabolism, CAR, signal transduction, nuclear receptors, xenobiotics, gene expression, carcinogenesis. He got the title of "The best junior scientist in 2011" from the Novosibirsk government award. In 2012-14 he was PI of Foundation for innovation (Promotion of Small Innovative Enterprises in Science and Technology Foundation, the "Member of the Youth Research and Innovation Competition" program) grant. In 2014-19 he is PI of Russian Foundation of Basic Research grant «mol_a».

Career opportunities

The obtained theoretical knowledge and practical skills will allow graduates of the program to successfully realize their scientific career in the leading scientific research institutions of Russia and abroad (R&D – research and development). Besides graduates of the program will be able to find good positions in the pharmacological companies that are currently highly developing and really need for such specialists. In addition, the development of the production of modern drugs also requires highly qualified specialists in the field of pharmaceutical chemistry.

Entrance requirements

  • Copy of the 1st page of your travelling passport with your personal data
  • Legalized (if required) educational certificate
  • Legalized (if required) academic transcripts (transcript of record, university degree/s, diploma supplements)
  • 2 photos
  • English language course marks sheet/TOEFL certificate or other international certificates (in case English is not your mother tongue and your previous education wasn't in English)
  • Curriculum Vitae
  • Motivation Letter (1-2 pages)
  • Medical certificate of overall health condition
  • HIV + AIDS certificates

Note! For enrollment you have to submit both original and notarized Russian translations of the required documents to the NSU Admission Office.

Application deadlines

Application is over