The main objective of the laboratory is the development of new antiviral and antitumor drugs on the basis of available natural compounds, and mainly monoterpenoids.
The use of natural compounds as the basis for the development of new drugs is one of the most important trends of modern medicinal chemistry. This is largely due to the inherent complementarity of natural substances to many targets in the organism, the presence of substantial amounts of saturated carbon atoms and asymmetric centers. One of the most common natural compounds is monoterpenoids. So far, monoterpenoids role in the creation of new drugs is low because of the difficulties relative to their chemical modification.
Main results from the laboratory:
- For the first time a method of selective catalytic hydrogenation was developed using nanosized gold catalysts in order to obtain dihydrocarvone - a valuable precursor for biologically active substances;
- On the basis of common natural substances was held the targeted synthesis of a large range of new compounds took place, which is promising for the study of their biological activity;
- As a result of studies on the antitumor activity of obtained substances were determined highly active compounds-leaders were established, which is promising for further development;
- Discovery of compounds that develop high activity against Influenza.
Laboratory research is conducted in partnership with the Research Institute of Influenza in St Petersburg, the University of Auckland (Auckland, New Zealand) and the Academy of Abo (Turku, Finland.)
Expert in this field
– Doctor of Chemical Sciences Nariman F. Salakhutdinov, firstname.lastname@example.org
Institute of Medicine and Psychology NSU
Novosibirsk Institute of organic chemistry, Siberian Branch of the Russian Academy of Sciences
Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences
Institute of Chemical Biology and Fundamental Medicine,Siberian Branch of the Russian Academy of Sciences