As part of the laboratory research molecular design, development of methods for the synthesis and study of properties of new stable organic radicals (nitroxide, triarylmethyl) for various applications (in biophysics, structural biology, medicine, materials science, etc.) are conducted. The study of stable chalcogen-diazol ions radical has been carried out. On their basis, new magnetic materials and other materials for organic electronics are being developed. Using synthesized spin labels the interaction of protein molecules and nucleic acids is studied. Such interaction plays the key role in the life of living systems and the development of pathological processes. The role of free radicals in the aging process as well as the influence of antioxidants of different nature on the development of senile pathologies has been studied.
The results of the laboratory research are the following:
Head of Laboratory:
- The ability of the mitochondrial antioxidant SkQ1 to hinder the development associated with the activation of free radical processes of age-related diseases has been studied;
- A large set of new spin labels based on trityl radicals and nitroxyl radicals with spirocyclic fragments surrounded by a nitroxyl group, distinguished by their high electron spin relaxation time has been synthesized;
- Methodology of synthesis has been developed and a number of stable nitroxyl radicals of 2,5-dihydroimidazole type have been obtained. Such radicals contain the fragment of heterocycle moiety ortho-hydroxyphenyl in the 4th-position, so-called paramagnetic Schiff base; The formation of unusual tridentate mono and binuclear complexes of 2- (o-pyridyl) substituted radical with hexafluoroacetylacetonate and copper acetate, respectively, has been demonstrated;
- Antihypertensive activity of mitochondria-targeted nitroxides pyrrolidine type has been studied.
Doctor in Chemistry, Prof. Vladimir A. Reznikov, email@example.com
Division of Organic Chemistry Department of Natural Sciences NSU
V. V. Voevodskiy Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences